tag:blogger.com,1999:blog-7656480992476344898.post7301186192859217155..comments2024-03-03T10:24:44.619-08:00Comments on The Gleason / Gleeson DNA Project: Building a Mutation History Tree with STR dataMaurice Gleesonhttp://www.blogger.com/profile/03920753459154271648noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-7656480992476344898.post-14802468212937274912015-08-19T14:43:59.887-07:002015-08-19T14:43:59.887-07:00Thanks Debbie. I suspect the hand-drawn Mutation H...Thanks Debbie. I suspect the hand-drawn Mutation History Tree (MHT) is likely to be biased by the fact that we tend to start with the Panel 1 markers (1-12), then proceed to the Panel 2 set (13-25), etc. We might get a different tree if we started at the other end i.e. Panel 5 first (markers 68-11), then Panel 4 (38-67), etc.<br /><br />Also, the rapidly-mutating markers may easily skew the results if added in to the MHT too soon. I think a less risky approach might be to leave them till last, and start with the slow mutating markers. This will be particularly important for larger genetic families, with a common ancestor pre-surnames. Maurice Gleesonhttps://www.blogger.com/profile/03920753459154271648noreply@blogger.comtag:blogger.com,1999:blog-7656480992476344898.post-83974707702757626892015-08-19T14:34:44.402-07:002015-08-19T14:34:44.402-07:00An excellent article Maurice. I shall be fascinate...An excellent article Maurice. I shall be fascinated to see how the picture changes with the inclusion of SNP data!Debbie Kennetthttps://www.blogger.com/profile/11573470282571579765noreply@blogger.comtag:blogger.com,1999:blog-7656480992476344898.post-25981366854084983182015-08-13T07:10:01.959-07:002015-08-13T07:10:01.959-07:00A fascinating article Maurice. Thank you. I will t...A fascinating article Maurice. Thank you. I will take some time to red and absorb this information. Thanks again DamianAnonymoushttps://www.blogger.com/profile/10205494723131854334noreply@blogger.comtag:blogger.com,1999:blog-7656480992476344898.post-70746749646587006402015-08-13T05:18:47.001-07:002015-08-13T05:18:47.001-07:00Thanks Margaret. It's an exciting time for Mut...Thanks Margaret. It's an exciting time for Mutation History Trees now that SNP data is beginning to come in. The next post will show how SNP data paints an entirely new picture and raises some important issues about our previous assumptions! :-)Maurice Gleesonhttps://www.blogger.com/profile/03920753459154271648noreply@blogger.comtag:blogger.com,1999:blog-7656480992476344898.post-21344856824887671142015-08-13T04:55:38.717-07:002015-08-13T04:55:38.717-07:00Wonderful! We've been working on a similar an...Wonderful! We've been working on a similar analysis with our Towne DNA project and I've been trying to articulate and illustrate for years what you've done so well here. We have the benefit of 30+ men with solid paper trails back to their shared immigrant ancestor b 1599. Parallel and back-mutations have been a real disappointment, though. We are now working with SNPs as well, with one Big-Y in the group. Thank you for this great article!Anonymoushttps://www.blogger.com/profile/04162636078176863138noreply@blogger.com